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As shown in Scheme 7, Heck-type cross-couplings can be performed by suspending a halogenated tetracycline compound (eg, 7-iodosancycline, 7A) and an appropriate palladium or other transition metal catalyst (eg, Pd(OAc)2 and CuI) in an appropriate solvent (eg, degassed acetonitrile). • Andrew Weddington CRAIG and Francis Marion Anthony v.

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25-75 mg was used more for pain killer and sleep disorder while the higher doseages ie.